Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities
نویسندگان
چکیده
منابع مشابه
White Matter Hyperintensities among Older Adults Are Associated with Futile Increase in Frontal Activation and Functional Connectivity during Spatial Search
The mechanisms by which aging and other processes can affect the structure and function of brain networks are important to understanding normal age-related cognitive decline. Advancing age is known to be associated with various disease processes, including clinically asymptomatic vascular and inflammation processes that contribute to white matter structural alteration and potential injury. The ...
متن کاملLocalization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults.
BACKGROUND Because white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) may be linked to geriatric syndromes involving mobility, cognition, and affect, we postulated that involvement of areas critical to bladder control could influence urinary incontinence (UI). METHODS One hundred community-dwelling individuals (75-89 years) were recruited into three groups stratified by ...
متن کاملWhite matter hyperintensities predict functional decline in voiding, mobility, and cognition in older adults.
OBJECTIVES To compare magnetic resonance imaging data with functional assessments of mobility, urinary control, and cognition to determine common or distinctive features in the distribution of brain white matter hyperintensities (WMHs) associated with functional decline and impairment. DESIGN Baseline data from subjects aged 75 to 89 enrolled in a longitudinal study. Assessors and subjects we...
متن کاملEndothelial function and white matter hyperintensities in older adults with cardiovascular disease.
BACKGROUND AND PURPOSE The presence of white matter hyperintensities on brain MRI is common among elderly individuals. Previous research suggests that cardiovascular risk factors are associated with increased white matter hyperintensities. Examining the role of direct physiological measures of vascular function will help to clarify the vascular mechanisms related to white matter hyperintensitie...
متن کاملLower cardiac output is associated with greater white matter hyperintensities in older adults with cardiovascular disease.
OBJECTIVES To preliminarily examine the association between cardiac output, a measure of systemic blood flow, and structural brain magnetic resonance imaging indices of white matter hyperintensities (WMHs). DESIGN Cross-sectional. SETTING University medical setting. PARTICIPANTS Thirty-six older adults without dementia with prevalent cardiovascular disease (aged 56-85). MEASUREMENTS Car...
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ژورنال
عنوان ژورنال: NeuroImage
سال: 2015
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2015.05.054